choosing from whole cell and acellular pertussis vaccines- dilemma for the developing countries
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چکیده
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منابع مشابه
Choosing from Whole Cell and Acellular Pertussis Vaccines-Dilemma for the Developing Countries
Pertussis or whooping cough is a highly infectious , vaccine preventable, acute respiratory tract disease. Historically, it is a disease of infants and children, but recent data reveals pertussis cases from patients of all ages and gender (1). Of particular importance are the cases of atypical, adolescent and adult pertussis, characterized by persistent cough. Both typical as well atypical pert...
متن کاملWhole-cell and acellular pertussis vaccines.
OBJECTIVE To provide a review of pertussis vaccines, including information on efficacy, adverse reactions, and antibody production following administration of both whole-cell and acellular pertussis vaccines. DATA SOURCES A MEDLINE search and extensive review of journals was conducted to identify the information for this review. DATA EXTRACTION Pertinent studies reporting experience with pe...
متن کاملAcellular pertussis vaccines pertinent issues.
Efficacy of whole cell pertussis vaccines (wP) in humans correlates with (and hence is measured by) the ‘mouse protection test’, wherein vaccinated mice are challenged with live B. pertussis. This test does not work similarly with acellular pertussis vaccines (aP); hence antibody levels to various antigens are measured as a surrogate marker of efficacy. This difference between the direct as com...
متن کاملLimitations of acellular pertussis vaccines
Although humans are typically willing to punish so-called free riders—people who use public resources without contributing to them—most people balk at sanctioning community members who refuse to punish others. Modern societies usually address this threat to collective action by installing central authorities such as police and judicial systems that punish both free riders and individuals who re...
متن کاملEstimating the effectiveness of acellular pertussis vaccines.
TO THE EDITOR—In the 15 June 2012 issue of Clinical Infectious Diseases, Witt et al reported that vaccine effectiveness (VE) of acellular pertussis vaccines was 41% for children aged 2–7 years, 24% for 8to 12-year-olds, and 79% for 13to 18-year-olds [1]. The authors conclude that their data “confirms markedly lower than expected protection afforded by the pre-school series of acellular pertussi...
متن کاملNew approaches in pertussis vaccines for developing countries
The currently available pertussis vaccines are highly efficacious. However, whole cell vaccines display some reactogenicity and acellular vaccines are less toxic, but elevated costs limit their use in developing countries. Instituto Butantan, Brasil, has developed a new technology to remove lipopolysaccharides from the whole cell vaccine using a simplified and not expensive methodology, which a...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۶، شماره ۲، صفحات ۲۷۲-۲۷۳
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